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Ancient human genomes suggest three ancestral populations for present-day Europeans.


ABSTRACT: We sequenced the genomes of a ?7,000-year-old farmer from Germany and eight ?8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had ?44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages.

SUBMITTER: Lazaridis I 

PROVIDER: S-EPMC4170574 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Ancient human genomes suggest three ancestral populations for present-day Europeans.

Lazaridis Iosif I   Patterson Nick N   Mittnik Alissa A   Renaud Gabriel G   Mallick Swapan S   Kirsanow Karola K   Sudmant Peter H PH   Schraiber Joshua G JG   Castellano Sergi S   Lipson Mark M   Berger Bonnie B   Economou Christos C   Bollongino Ruth R   Fu Qiaomei Q   Bos Kirsten I KI   Nordenfelt Susanne S   Li Heng H   de Filippo Cesare C   Prüfer Kay K   Sawyer Susanna S   Posth Cosimo C   Haak Wolfgang W   Hallgren Fredrik F   Fornander Elin E   Rohland Nadin N   Delsate Dominique D   Francken Michael M   Guinet Jean-Michel JM   Wahl Joachim J   Ayodo George G   Babiker Hamza A HA   Bailliet Graciela G   Balanovska Elena E   Balanovsky Oleg O   Barrantes Ramiro R   Bedoya Gabriel G   Ben-Ami Haim H   Bene Judit J   Berrada Fouad F   Bravi Claudio M CM   Brisighelli Francesca F   Busby George B J GB   Cali Francesco F   Churnosov Mikhail M   Cole David E C DE   Corach Daniel D   Damba Larissa L   van Driem George G   Dryomov Stanislav S   Dugoujon Jean-Michel JM   Fedorova Sardana A SA   Gallego Romero Irene I   Gubina Marina M   Hammer Michael M   Henn Brenna M BM   Hervig Tor T   Hodoglugil Ugur U   Jha Aashish R AR   Karachanak-Yankova Sena S   Khusainova Rita R   Khusnutdinova Elza E   Kittles Rick R   Kivisild Toomas T   Klitz William W   Kučinskas Vaidutis V   Kushniarevich Alena A   Laredj Leila L   Litvinov Sergey S   Loukidis Theologos T   Mahley Robert W RW   Melegh Béla B   Metspalu Ene E   Molina Julio J   Mountain Joanna J   Näkkäläjärvi Klemetti K   Nesheva Desislava D   Nyambo Thomas T   Osipova Ludmila L   Parik Jüri J   Platonov Fedor F   Posukh Olga O   Romano Valentino V   Rothhammer Francisco F   Rudan Igor I   Ruizbakiev Ruslan R   Sahakyan Hovhannes H   Sajantila Antti A   Salas Antonio A   Starikovskaya Elena B EB   Tarekegn Ayele A   Toncheva Draga D   Turdikulova Shahlo S   Uktveryte Ingrida I   Utevska Olga O   Vasquez René R   Villena Mercedes M   Voevoda Mikhail M   Winkler Cheryl A CA   Yepiskoposyan Levon L   Zalloua Pierre P   Zemunik Tatijana T   Cooper Alan A   Capelli Cristian C   Thomas Mark G MG   Ruiz-Linares Andres A   Tishkoff Sarah A SA   Singh Lalji L   Thangaraj Kumarasamy K   Villems Richard R   Comas David D   Sukernik Rem R   Metspalu Mait M   Meyer Matthias M   Eichler Evan E EE   Burger Joachim J   Slatkin Montgomery M   Pääbo Svante S   Kelso Janet J   Reich David D   Krause Johannes J  

Nature 20140901 7518


We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to  ...[more]

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