Ontology highlight
ABSTRACT:
SUBMITTER: Tomlinson G
PROVIDER: S-EPMC4170674 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Tomlinson Gillian G Chimalapati Suneeta S Pollard Tracey T Lapp Thabo T Cohen Jonathan J Camberlein Emilie E Stafford Sian S Periselneris Jimstan J Aldridge Christine C Vollmer Waldemar W Picard Capucine C Casanova Jean-Laurent JL Noursadeghi Mahdad M Brown Jeremy J
Journal of immunology (Baltimore, Md. : 1950) 20140829 7
Streptococcus pneumoniae infections induce inflammatory responses that contribute toward both disease pathogenesis and immunity, but the host-pathogen interactions that mediate these effects are poorly defined. We used the surface lipoprotein-deficient ∆lgt pneumococcal mutant strain to test the hypothesis that lipoproteins are key determinants of TLR-mediated immune responses to S. pneumoniae. We show using reporter assays that TLR2 signaling is dependent on pneumococcal lipoproteins, and that ...[more]