Ontology highlight
ABSTRACT:
SUBMITTER: Sundaram K
PROVIDER: S-EPMC5012667 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Sundaram Kruthika K Rahman Mohd Akhlakur MA Mitra Srabani S Knoell Daren L DL Woodiga Shireen A SA King Samantha J SJ Wewers Mark D MD
PloS one 20160906 9
Pneumococcal lung infections represent a major cause of death worldwide. Single nucleotide polymorphisms (SNPs) in the NFKBIZ gene, encoding the transcription factor IκBζ, are associated with increased susceptibility to invasive pneumococcal disease. We hence analyzed how IκBζ might regulate inflammatory responses to pneumococcal infection. We first demonstrate that IκBζ is expressed in human blood monocytes but not in bronchial epithelial cells, in response to wild type pneumococcal strain D39. ...[more]