Extended-release niacin acutely suppresses postprandial triglyceridemia.

ABSTRACT:

Objective

Postprandial triglyceridemia predicts cardiovascular events. Niacin might lower postprandial triglycerides by restricting free fatty acids. Immediate-release niacin reduced postprandial triglycerides, but extended-release niacin failed to do so when dosed the night before a fat challenge. The study aims were to determine whether extended-release niacin dosed before a fat challenge suppresses postprandial triglycerides and whether postprandial triglycerides are related to free fatty acid restriction.

Methods

A double-blinded, placebo-controlled, random-order crossover experiment was performed, in which healthy volunteers took 2 g extended-release niacin or placebo 1 hour before heavy cream. We sampled blood over 12 hours and report triglycerides and free fatty acid

SUBMITTER: Usman MH 

PROVIDER: S-EPMC4170918 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature