Ontology highlight
ABSTRACT:
SUBMITTER: Yu F
PROVIDER: S-EPMC4171397 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Yu Fang F Chen Ming-Hui MH Kuo Lynn L Huang Peng P Yang Wanling W
Biometrics 20110301 1
Expressed sequence tag (EST) sequencing is a one-pass sequencing reading of cloned cDNAs derived from a certain tissue. The frequency of unique tags among different unbiased cDNA libraries is used to infer the relative expression level of each tag. In this article, we propose a hierarchical multinomial model with a nonlinear Dirichlet prior for the EST data with multiple libraries and multiple types of tissues. A novel hierarchical prior is developed and the properties of the proposed prior are ...[more]