Ontology highlight
ABSTRACT:
SUBMITTER: Fitzpatrick JM
PROVIDER: S-EPMC4172209 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Fitzpatrick Jeremy M JM Pellegrini Maria M Cushing Patrick R PR Mierke Dale F DF
Biochemistry 20140915 37
We have identified a series of small molecules that bind to the canonical peptide binding groove of the PDZ1 domain of NHERF1 and effectively compete with the association of the C-terminus of the parathyroid hormone 1 receptor (PTH1R). Employing nuclear magnetic resonance and molecular modeling, we characterize the mode of binding that involves the GYGF loop important for the association of the C-terminus of PTH1R. We demonstrate that the common core of the small molecules binds to the PDZ1 doma ...[more]