Ontology highlight
ABSTRACT:
SUBMITTER: Ferrandez Y
PROVIDER: S-EPMC5663973 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Ferrandez Yann Y Zhang Wenhua W Peurois François F Akendengué Lurlène L Blangy Anne A Zeghouf Mahel M Cherfils Jacqueline J
Scientific reports 20171031 1
Rac small GTPases and their GEFs of the DOCK family are pivotal checkpoints in development, autoimmunity and bone homeostasis, and their abnormal regulation is associated to diverse pathologies. Small molecules that inhibit their activities are therefore needed to investigate their functions. Here, we characterized the mechanism of inhibition of human DOCK5 by C21, a small molecule that inhibits mouse Dock5 in cells and blocks bone degradation in mice models of osteoporosis. We showed that the c ...[more]