Ontology highlight
ABSTRACT:
SUBMITTER: Ma JS
PROVIDER: S-EPMC4172224 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Ma Ji Su JS Sasai Miwa M Ohshima Jun J Lee Youngae Y Bando Hironori H Takeda Kiyoshi K Yamamoto Masahiro M
The Journal of experimental medicine 20140915 10
Toxoplasma gondii infection results in co-option and subversion of host cellular signaling pathways. This process involves discharge of T. gondii effector molecules from parasite secretory organelles such as rhoptries and dense granules. We report that the T. gondii polymorphic dense granule protein GRA6 regulates activation of the host transcription factor nuclear factor of activated T cells 4 (NFAT4). GRA6 overexpression robustly and selectively activated NFAT4 via calcium modulating ligand (C ...[more]