Ontology highlight
ABSTRACT:
SUBMITTER: Kaneko S
PROVIDER: S-EPMC4173153 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Kaneko Syuzo S Son Jinsook J Bonasio Roberto R Shen Steven S SS Reinberg Danny D
Genes & development 20140828 18
Polycomb-repressive complex 2 (PRC2) facilitates the maintenance and inheritance of chromatin domains repressive to transcription through catalysis of methylation of histone H3 at Lys27 (H3K27me2/3). However, through its EZH2 subunit, PRC2 also binds to nascent transcripts from active genes that are devoid of H3K27me2/3 in embryonic stem cells. Here, biochemical analyses indicated that RNA interaction inhibits SET domain-containing proteins, such as PRC2, nonspecifically in vitro. However, CRISP ...[more]