Unknown

Dataset Information

0

Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity.


ABSTRACT: Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we define a molecular interaction between neurons and microglia that drives experience-dependent synapse remodeling in the hippocampus. We find that the cytokine interleukin-33 (IL-33) is expressed by adult hippocampal neurons in an experience-dependent manner and defines a neuronal subset primed for synaptic plasticity. Loss of neuronal IL-33 or the microglial IL-33 receptor leads to impaired spine plasticity, reduced newborn neuron integration, and diminished precision of remote fear memories. Memory precision and neuronal IL-33 are decreased in aged mice, and IL-33 gain of function mitigates age-related decreases in spine plasticity. We find that neuronal IL-33 instructs microglial engulfment of the extracellular matrix (ECM) and that its loss leads to impaired ECM engulfment and a concomitant accumulation of ECM proteins in contact with synapses. These data define a cellular mechanism through which microglia regulate experience-dependent synapse remodeling and promote memory consolidation.

SUBMITTER: Nguyen PT 

PROVIDER: S-EPMC7497728 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

2020-07-01 | GSE150714 | GEO
2020-07-01 | GSE150712 | GEO
2020-07-01 | GSE150713 | GEO
| PRJNA633361 | ENA
| PRJNA633363 | ENA
| PRJNA633364 | ENA
| S-EPMC6034485 | biostudies-literature
| S-EPMC8139267 | biostudies-literature
| S-EPMC7531623 | biostudies-literature
| S-EPMC6880774 | biostudies-literature