Ontology highlight
ABSTRACT:
SUBMITTER: Colvin TA
PROVIDER: S-EPMC4174322 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Colvin Teresa A TA Gabai Vladimir L VL Gong Jianlin J Calderwood Stuart K SK Li Hu H Gummuluru Suryaram S Matchuk Olga N ON Smirnova Svetlana G SG Orlova Nina V NV Zamulaeva Irina A IA Garcia-Marcos Mikel M Li Xiaokai X Young Z T ZT Rauch Jennifer N JN Gestwicki Jason E JE Takayama Shinichi S Sherman Michael Y MY
Cancer research 20140703 17
Bag3, a nucleotide exchange factor of the heat shock protein Hsp70, has been implicated in cell signaling. Here, we report that Bag3 interacts with the SH3 domain of Src, thereby mediating the effects of Hsp70 on Src signaling. Using several complementary approaches, we established that the Hsp70-Bag3 module is a broad-acting regulator of cancer cell signaling by modulating the activity of the transcription factors NF-κB, FoxM1, Hif1α, the translation regulator HuR, and the cell-cycle regulators ...[more]