Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC4456214 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Li Xiaokai X Colvin Teresa T Rauch Jennifer N JN Acosta-Alvear Diego D Kampmann Martin M Dunyak Bryan B Hann Byron B Aftab Blake T BT Murnane Megan M Cho Min M Walter Peter P Weissman Jonathan S JS Sherman Michael Y MY Gestwicki Jason E JE
Molecular cancer therapeutics 20150106 3
Hsp70 is a stress-inducible molecular chaperone that is required for cancer development at several steps. Targeting the active site of Hsp70 has proven relatively challenging, driving interest in alternative approaches. Hsp70 collaborates with the Bcl2-associated athanogene 3 (Bag3) to promote cell survival through multiple pathways, including FoxM1. Therefore, inhibitors of the Hsp70-Bag3 protein-protein interaction (PPI) may provide a noncanonical way to target this chaperone. We report that J ...[more]