Ontology highlight
ABSTRACT:
SUBMITTER: Markowitz J
PROVIDER: S-EPMC4174542 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Markowitz Joseph J Luedke Eric A EA Grignol Valerie P VP Hade Erinn M EM Paul Bonnie K BK Mundy-Bosse Bethany L BL Brooks Taylor R TR Dao Thao-Vi TV Kondalasula Sri V SV Lesinski Gregory B GB Olencki Thomas T Kendra Kari L KL Carson William E WE
Journal of immunotherapy (Hagerstown, Md. : 1997) 20140101 1
The possibility that cytokine administration could enhance the antitumor effects of proteasome inhibition was explored. It was found that coadministration of bortezomib and interferon-α (IFN-α) induced synergistic apoptosis in human melanoma cell lines and prolonged survival in a murine model of melanoma. A phase I study was conducted to determine the tolerability and the maximum tolerated dose of bortezomib when administered in combination with IFN-α-2b to patients with metastatic melanoma. Pat ...[more]