Ontology highlight
ABSTRACT:
SUBMITTER: Oberbeck N
PROVIDER: S-EPMC4175174 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Oberbeck Nina N Langevin Frédéric F King Gareth G de Wind Niels N Crossan Gerry P GP Patel Ketan J KJ
Molecular cell 20140821 6
Maternal metabolism provides essential nutrients to enable embryonic development. However, both mother and embryo produce reactive metabolites that can damage DNA. Here we discover how the embryo is protected from these genotoxins. Pregnant mice lacking Aldh2, a key enzyme that detoxifies reactive aldehydes, cannot support the development of embryos lacking the Fanconi anemia DNA repair pathway gene Fanca. Remarkably, transferring Aldh2(-/-)Fanca(-/-) embryos into wild-type mothers suppresses de ...[more]