Ontology highlight
ABSTRACT:
SUBMITTER: Kai X
PROVIDER: S-EPMC4175336 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20140808 39
Somatic mutations altering lysine 171 of the IKBKB gene that encodes (IKKβ), the critical activating kinase in canonical (NFκB) signaling, have been described in splenic marginal zone lymphomas and multiple myeloma. Lysine 171 forms part of a cationic pocket that interacts with the activation loop phosphate in the activated wild type kinase. We show here that K171E IKKβ and K171T IKKβ represent kinases that are constitutively active even in the absence of activation loop phosphorylation. Predict ...[more]