Ontology highlight
ABSTRACT:
SUBMITTER: Ramsey KM
PROVIDER: S-EPMC6642826 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Ramsey Kristen M KM Chen Wei W Marion James D JD Bergqvist Simon S Komives Elizabeth A EA
Biochemistry 20190514 21
The NFκB transcription factor family members RelA, p50, and cRel form homo- and heterodimers that are inhibited by IκBα, IκBβ, and IκBε. These NFκB family members have diverse biological functions, and their expression profiles differ, leading to different concentrations in different tissue types. Here we present definitive biophysical measurements of the NFκB dimer affinities and inhibitor affinities to better understand dimer exchange and how the presence of inhibitors may alter the equilibriu ...[more]