Doxycycline enhances survival and self-renewal of human pluripotent stem cells.
Ontology highlight
ABSTRACT:
SUBMITTER: Chang MY
PROVIDER: S-EPMC4175555 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
Doxycycline enhances survival and self-renewal of human pluripotent stem cells.
Chang Mi-Yoon MY Rhee Yong-Hee YH Yi Sang-Hoon SH Lee Su-Jae SJ Kim Rae-Kwon RK Kim Hyongbum H Park Chang-Hwan CH Lee Sang-Hun SH
Stem cell reports 20140724 2
We here report that doxycycline, an antibacterial agent, exerts dramatic effects on human embryonic stem and induced pluripotent stem cells (hESC/iPSCs) survival and self-renewal. The survival-promoting effect was also manifest in cultures of neural stem cells (NSCs) derived from hESC/iPSCs. These doxycycline effects are not associated with its antibacterial action, but mediated by direct activation of a PI3K-AKT intracellular signal. These findings indicate doxycycline as a useful supplement fo ...[more]
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