Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1.
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ABSTRACT:
SUBMITTER: El Omari K
PROVIDER: S-EPMC4175578 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1.
El Omari Kamel K Iourin Oleg O Kadlec Jan J Sutton Geoff G Harlos Karl K Grimes Jonathan M JM Stuart David I DI
Nature communications 20140916
Hepatitis C virus (HCV) infection remains a major health problem worldwide. HCV entry into host cells and membrane fusion are achieved by two envelope glycoproteins, E1 and E2. We report here the 3.5-Å resolution crystal structure of the N-terminal domain of the HCV E1 ectodomain, which reveals a complex network of covalently linked intertwined homodimers that do not harbour the expected truncated class II fusion protein fold. ...[more]
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