Ontology highlight
ABSTRACT:
SUBMITTER: Tong Y
PROVIDER: S-EPMC6018474 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Tong Yimin Y Lavillette Dimitri D Li Qingchao Q Zhong Jin J
Frontiers in immunology 20180619
Hepatitis C virus (HCV) glycoproteins E1 and E2 form a heterodimer to constitute viral envelope proteins, which play an essential role in virus entry. E1 does not directly interact with host receptors, and its functions in viral entry are exerted mostly through its interaction with E2 that directly binds the receptors. HCV enters the host cell <i>via</i> receptor-mediated endocytosis during which the fusion of viral and host endosomal membranes occurs to release viral genome to cytoplasm. A puta ...[more]