Ontology highlight
ABSTRACT:
SUBMITTER: Konieczny P
PROVIDER: S-EPMC4176163 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Nucleic acids research 20140902 17
Muscleblind-like (MBNL) proteins are key regulators of precursor and mature mRNA metabolism in mammals. Based on published and novel data, we explore models of tissue-specific MBNL interaction with RNA. We portray MBNL domains critical for RNA binding and splicing regulation, and the structure of MBNL's normal and pathogenic RNA targets, particularly in the context of myotonic dystrophy (DM), in which expanded CUG or CCUG repeat transcripts sequester several nuclear proteins including MBNLs. We ...[more]