Ontology highlight
ABSTRACT:
SUBMITTER: Biela A
PROVIDER: S-EPMC4176347 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Biela Artur A Coste Franck F Culard Françoise F Guerin Martine M Goffinont Stéphane S Gasteiger Karola K Cieśla Jarosław J Winczura Alicja A Kazimierczuk Zygmunt Z Gasparutto Didier D Carell Thomas T Tudek Barbara B Castaing Bertrand B
Nucleic acids research 20140820 16
DNA glycosylases from the Fpg/Nei structural superfamily are base excision repair enzymes involved in the removal of a wide variety of mutagen and potentially lethal oxidized purines and pyrimidines. Although involved in genome stability, the recent discovery of synthetic lethal relationships between DNA glycosylases and other pathways highlights the potential of DNA glycosylase inhibitors for future medicinal chemistry development in cancer therapy. By combining biochemical and structural appro ...[more]