Ontology highlight
ABSTRACT:
SUBMITTER: Prakash A
PROVIDER: S-EPMC4101889 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Prakash Aishwarya A Doublié Sylvie S Wallace Susan S SS
Progress in molecular biology and translational science 20120101
During the initial stages of the base excision DNA repair pathway, DNA glycosylases are responsible for locating and removing the majority of endogenous oxidative base lesions. The bifunctional formamidopyrimidine DNA glycosylase (Fpg) and endonuclease VIII (Nei) are members of the Fpg/Nei family, one of the two families of glycosylases that recognize oxidized DNA bases, the other being the HhH/GPD (or Nth) superfamily. Structural and biochemical developments over the past decades have led to no ...[more]