Ontology highlight
ABSTRACT:
SUBMITTER: Chanda S
PROVIDER: S-EPMC4176533 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Stem cell reports 20140704 2
Direct conversion of nonneural cells to functional neurons holds great promise for neurological disease modeling and regenerative medicine. We previously reported rapid reprogramming of mouse embryonic fibroblasts (MEFs) into mature induced neuronal (iN) cells by forced expression of three transcription factors: ASCL1, MYT1L, and BRN2. Here, we show that ASCL1 alone is sufficient to generate functional iN cells from mouse and human fibroblasts and embryonic stem cells, indicating that ASCL1 is t ...[more]