Ontology highlight
ABSTRACT:
SUBMITTER: Laurent-Rolle M
PROVIDER: S-EPMC4176702 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Cell host & microbe 20140901 3
To successfully establish infection, flaviviruses have to overcome the antiviral state induced by type I interferon (IFN-I). The nonstructural NS5 proteins of several flaviviruses antagonize IFN-I signaling. Here we show that yellow fever virus (YFV) inhibits IFN-I signaling through a unique mechanism that involves binding of YFV NS5 to the IFN-activated transcription factor STAT2 only in cells that have been stimulated with IFN-I. This NS5-STAT2 interaction requires IFN-I-induced tyrosine phosp ...[more]