Ontology highlight
ABSTRACT:
SUBMITTER: Lin S
PROVIDER: S-EPMC6340140 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Lin Shaoli S Yang Shixing S He Jia J Guest Johnathan D JD Ma Zexu Z Yang Liping L Pierce Brian G BG Tang Qiyi Q Zhang Yan-Jin YJ
Virology 20181206
Zika virus (ZIKV) is a mosquito-borne positive-sense single-stranded RNA virus in the family of Flaviviridae. Unlike other flaviviruses, ZIKV infection of pregnant women may result in birth defects in their newborns, such as microcephaly or vision problem. ZIKV is known to antagonize the interferon (IFN) production in infected cells. However, the exact mechanism of this interference is not fully understood. Here, we demonstrate that NS5 protein of ZIKV MR766 strain antagonizes IFN production thr ...[more]