Expression of the diabetes-associated gene TCF7L2 in adult mouse brain.
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ABSTRACT:
SUBMITTER: Lee S
PROVIDER: S-EPMC4176933 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Publications
Expression of the diabetes-associated gene TCF7L2 in adult mouse brain.
Lee Syann S Lee Charlotte E CE Elias Carol F CF Elmquist Joel K JK
The Journal of comparative neurology 20091201 6
Polymorphisms of the gene TCF7L2 (transcription factor 7-like 2) are strongly associated with the development and progression of type 2 diabetes. TCF7L2 is important in the development of peripheral organs such as adipocytes, pancreas, and the intestine. However, very little is known about its expression elsewhere. In this study we used in situ hybridization histochemistry to show that TCF7L2 has a unique expression pattern in the mouse brain. TCF7L2 is expressed in two distinct populations. Fir ...[more]
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