Unknown

Dataset Information

0

A survey of membrane proteins in human serum.


ABSTRACT: Serum and membrane proteins are two of the most attractive targets for proteomic analysis. Previous membrane protein studies tend to focus on tissue sample, while membrane protein studies in serum are still limited. In this study, an analysis of membrane proteins in normal human serum was carried out. Nano-liquid chromatography-electrospray ionization mass spectrometry (NanoLC-ESI-MS/MS) and bioinformatics tools were used to identify membrane proteins. Two hundred and seventeen membrane proteins were detected in the human serum, of which 129 membrane proteins have at least one transmembrane domain (TMD). Further characterizations of identified membrane proteins including their subcellular distributions, molecular weights, post translational modifications, transmembrane domains and average of hydrophobicity, were also implemented. Our results showed the potential of membrane proteins in serum for diagnosis and treatment of diseases.

SUBMITTER: Dung NT 

PROVIDER: S-EPMC4177280 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

altmetric image

Publications

A survey of membrane proteins in human serum.

Dung Nguyen Tien NT   Van Chi Phan P  

Proteomics insights 20120403


Serum and membrane proteins are two of the most attractive targets for proteomic analysis. Previous membrane protein studies tend to focus on tissue sample, while membrane protein studies in serum are still limited. In this study, an analysis of membrane proteins in normal human serum was carried out. Nano-liquid chromatography-electrospray ionization mass spectrometry (NanoLC-ESI-MS/MS) and bioinformatics tools were used to identify membrane proteins. Two hundred and seventeen membrane proteins  ...[more]

Similar Datasets

| S-EPMC2780624 | biostudies-literature
| S-EPMC7312639 | biostudies-literature
| S-EPMC5047454 | biostudies-literature
| S-EPMC4809138 | biostudies-literature
| S-EPMC7886145 | biostudies-literature
| S-EPMC5678787 | biostudies-literature
| S-EPMC6989408 | biostudies-literature
| S-EPMC2110644 | biostudies-literature
| S-EPMC4672057 | biostudies-literature
| S-EPMC6190714 | biostudies-literature