Ontology highlight
ABSTRACT:
SUBMITTER: Emilsson V
PROVIDER: S-EPMC6190714 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Emilsson Valur V Ilkov Marjan M Lamb John R JR Finkel Nancy N Gudmundsson Elias F EF Pitts Rebecca R Hoover Heather H Gudmundsdottir Valborg V Horman Shane R SR Horman Shane R SR Aspelund Thor T Shu Le L Trifonov Vladimir V Sigurdsson Sigurdur S Manolescu Andrei A Zhu Jun J Olafsson Örn Ö Jakobsdottir Johanna J Lesley Scott A SA To Jeremy J Zhang Jia J Harris Tamara B TB Launer Lenore J LJ Zhang Bin B Eiriksdottir Gudny G Yang Xia X Orth Anthony P AP Jennings Lori L LL Gudnason Vilmundur V
Science (New York, N.Y.) 20180802 6404
Proteins circulating in the blood are critical for age-related disease processes; however, the serum proteome has remained largely unexplored. To this end, 4137 proteins covering most predicted extracellular proteins were measured in the serum of 5457 Icelanders over 65 years of age. Pairwise correlation between proteins as they varied across individuals revealed 27 different network modules of serum proteins, many of which were associated with cardiovascular and metabolic disease states, as wel ...[more]