Ontology highlight
ABSTRACT:
SUBMITTER: Sparks JA
PROVIDER: S-EPMC4177324 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Sparks Jeffrey A JA Chen Chia-Yen CY Hiraki Linda T LT Malspeis Susan S Costenbader Karen H KH Karlson Elizabeth W EW
Arthritis care & research 20141001 10
<h4>Objective</h4>We assessed the contributions of familial rheumatoid arthritis (RA) or lupus and environmental factors to the risk of RA.<h4>Methods</h4>Among 121,700 women in the Nurses' Health Study, 65,457 provided data on familial RA/lupus. Among these, 493 RA cases (301 seropositive and 192 seronegative) were validated. We estimated hazard ratios (HRs) for RA comparing those with and without familial RA/lupus, adjusting for environmental factors (smoking, alcohol, body mass index [BMI], p ...[more]