Ontology highlight
ABSTRACT:
SUBMITTER: Oricchio E
PROVIDER: S-EPMC4177332 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Cell reports 20140918 6
The long-term risk of malignancy associated with stem cell therapies is a significant concern in the clinical application of this exciting technology. We report a cancer-selective strategy to enhance the safety of stem cell therapies. Briefly, using a cell engineering approach, we show that aggressive cancers derived from human or murine induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) are strikingly sensitive to temporary MYC blockade. On the other hand, differentiated tis ...[more]