Dataset Information

Relationship of adipocyte size with adiposity and metabolic risk factors in Asian Indians.

ABSTRACT:

Background

Enlargement of adipocyte is associated with their dysfunction and alterations in metabolic functions.

Objectives

We evaluated the association of adipocyte size of subcutaneous and omental adipose tissue with body composition and cardiovascular risk factors in Asian Indians.

Methodology

Eighty (40 males and 40 females) non-diabetic adult subjects undergoing elective abdominal surgery were included. Pre-surgery evaluation included anthropometric measurements, % body fat by bioimpedance, abdominal fat area at L2-3 level (computed tomography) and biochemical investigations (fasting blood glucose and insulin, lipids and hsCRP). During surgery, about 5 grams each of omental and subcutaneous adipose tissue was obtained for adipocyte size determination.

Results

Females had higher BMI, % body fat, skinfold thickness, total and subcutaneous abdominal fat area as compared to males. Overweight was present in 42.5% and 67.5%, and abdominal obesity in 5% and 52.5% males and females, respectively. Subcutaneous adipocyte size was significantly higher than omental adipocyte size. Omental adipocyte size correlated more strongly than subcutaneous adipocyte size with measures of adiposity (BMI, waist circumference, %BF), total and subcutaneous abdominal fat area and biochemical measures (fasting glucose, total cholesterol, triglycerides and HOMA-IR), the correlations being stronger in females. The correlation of adipocyte size with metabolic parameters was attenuated after adjusting for measures of adiposity.

Conclusion

Omental adipocyte size, though smaller than the subcutaneous adipocyte size, was more closely related to measures of adiposity and metabolic parameters. However, the relationship was not independent of measures of adiposity.

SUBMITTER: Meena VP

PROVIDER: S-EPMC4177391 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Relationship of adipocyte size with adiposity and metabolic risk factors in Asian Indians.

Meena Ved Prakash VP Seenu V V Sharma M C MC Mallick Saumya Ranjan SR Bhalla Ashu Seith AS Gupta Nandita N Mohan Anant A Guleria Randeep R Pandey Ravindra M RM Luthra Kalpana K Vikram Naval K NK

PloS one 20140924 9

<h4>Background</h4>Enlargement of adipocyte is associated with their dysfunction and alterations in metabolic functions.<h4>Objectives</h4>We evaluated the association of adipocyte size of subcutaneous and omental adipose tissue with body composition and cardiovascular risk factors in Asian Indians.<h4>Methodology</h4>Eighty (40 males and 40 females) non-diabetic adult subjects undergoing elective abdominal surgery were included. Pre-surgery evaluation included anthropometric measurements, % bod ...[more]

PMID: 25251402

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Project description:What is already known about this subject African Americans are disproportionately affected by obesity and other metabolic risk factors in comparison to White Americans. Increasing prevalence of obesity has been associated with concomitant increases in childhood hypertension, dyslipidaemia and type 2 diabetes. Oxidative stress is associated with obesity in both adults and children. What this study adds Oxidative stress is positively associated with total body fat and truncal fat, but not with body mass index (BMI) or BMI z-score in healthy youth. Oxidative stress is associated with diastolic blood pressure in African American but not in White American healthy youth.Oxidative stress is elevated in obese youth, but less is known regarding racial disparities in the relationship of oxidative stress with metabolic risk factors.To determine the relationship between oxidative stress and metabolic risk factors, adiposity, leptin, adiponectin and cardiovascular fitness (VO2PEAK ) in healthy African American and White American youth.A marker of oxidative stress (F2 -isoprostane), validated markers of metabolic risk factors, fitness and body composition were measured in African American (n?=?82) and White American (n?=?76) youth (8-17 years old) recruited over a range of BMI percentiles (4th to 99th).F2 -isoprostane concentration was positively correlated with percentage body fat (r?=?0.198) and percentage truncal fat (r?=?0.173), but was not different between African American and White American males and females (P?=?0.208). African American youth had significantly higher mean systolic and diastolic blood pressure (P?=?0.023 and P?=?0.011, respectively), body weight, BMI percentile and Tanner stage. After adjusting for gender, age, BMI and Tanner stage, African American youth varied from White Americans in the association of F2 -isoprostane with diastolic blood pressure (P?=?0.047), but not with systolic blood pressure, triglycerides, VO2PEAK or homeostatic model assessment for insulin resistance (all P?>?0.05).Oxidative stress, as measured by urinary F2 -isoprostane concentrations, was positively associated with percent body fat and truncal fat in youth. Oxidative stress levels were similar among African American and White American youth. Among markers of the metabolic syndrome, a significant difference between African American and White American youth was demonstrated only in the association of oxidative stress with diastolic blood pressure.

Dataset Information

Relationship of adipocyte size with adiposity and metabolic risk factors in Asian Indians.

Background

Objectives

Methodology

Results

Conclusion

Publications

Relationship of adipocyte size with adiposity and metabolic risk factors in Asian Indians.

Similar Datasets

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