Ontology highlight
ABSTRACT:
SUBMITTER: Oeckinghaus A
PROVIDER: S-EPMC4177457 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Oeckinghaus Andrea A Postler Thomas S TS Rao Ping P Schmitt Heike H Schmitt Verena V Grinberg-Bleyer Yenkel Y Kühn Lars I LI Gruber Christian W CW Lienhard Gustav E GE Ghosh Sankar S
Cell reports 20140915 6
The transformation of cells generally involves multiple genetic lesions that undermine control of both cell death and proliferation. We now report that κB-Ras proteins act as regulators of NF-κB and Ral pathways, which control inflammation/cell death and proliferation, respectively. Cells lacking κB-Ras therefore not only show increased NF-κB activity, which results in increased expression of inflammatory mediators, but also exhibit elevated Ral activity, which leads to enhanced anchorage-indepe ...[more]