Dataset Information

Expression of epidermal growth factor, transforming growth factor-?1 and adiponectin in nipple aspirate fluid and plasma of pre and post-menopausal women.

ABSTRACT:

Background

Nipple aspirate fluid (NAF) contains large amounts of protein thought to reflect the microenvironment of the breast, and is of interest in breast cancer prevention research. The correlation between specific NAF proteins to plasma concentrations have not been well studied in healthy women. We collected matched NAF and plasma from 43 healthy pre and postmenopausal women participating in an early phase clinical study to compare the levels of putative cancer protein biomarkers. We compared baseline NAF and plasma levels of epidermal growth factor (EGF), transforming growth factor-beta 1 (TGF-?1), and adiponectin and evaluated menopausal status and body mass index (BMI) as potential modifying factors.

Findings

NAF and plasma levels of EGF, TGF-?1 and adiponectin were not correlated. EGF and TGF-?1 levels in NAF of premenopausal women were significantly higher than postmenopausal women (P's?ConclusionsProtein biomarkers differ significantly between NAF and plasma and are affected differently by both BMI and menopausal status. This study demonstrates important differences in biological information gained by characterizing biomarkers in NAF compared to plasma and suggests each sample source may independently inform on breast cancer risk.

SUBMITTER: Miller JA

PROVIDER: S-EPMC4177617 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Publications

Expression of epidermal growth factor, transforming growth factor-β1 and adiponectin in nipple aspirate fluid and plasma of pre and post-menopausal women.

Miller Jessica A JA Thompson Patricia A PA Hakim Iman A IA Lopez Ana Maria AM Thomson Cynthia A CA Hsu Chiu-Hsieh CH Chow H-H Sherry HH

Biomarker research 20130415 1

<h4>Background</h4>Nipple aspirate fluid (NAF) contains large amounts of protein thought to reflect the microenvironment of the breast, and is of interest in breast cancer prevention research. The correlation between specific NAF proteins to plasma concentrations have not been well studied in healthy women. We collected matched NAF and plasma from 43 healthy pre and postmenopausal women participating in an early phase clinical study to compare the levels of putative cancer protein biomarkers. We ...[more]

PMID: 24252368

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