Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects.
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ABSTRACT:
SUBMITTER: Shi H
PROVIDER: S-EPMC4177696 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects.
Shi Huan H Sun Meili M Liu Lin L Wang Zhehai Z
Molecular cancer 20140921
Chimeric antigen receptors (CARs) are recombinant receptors that combine the specificity of an antigen-specific antibody with the T-cell's activating functions. Initial clinical trials of genetically engineered CAR T cells have significantly raised the profile of T cell therapy, and great efforts have been made to improve this approach. In this review, we provide a structural overview of the development of CAR technology and highlight areas that require further refinement. We also discuss critic ...[more]
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