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Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects.

ABSTRACT: Chimeric antigen receptors (CARs) are recombinant receptors that combine the specificity of an antigen-specific antibody with the T-cell's activating functions. Initial clinical trials of genetically engineered CAR T cells have significantly raised the profile of T cell therapy, and great efforts have been made to improve this approach. In this review, we provide a structural overview of the development of CAR technology and highlight areas that require further refinement. We also discuss critical issues related to CAR therapy, including the optimization of CAR T cells, the route of administration, CAR toxicity and the blocking of inhibitory molecules.

SUBMITTER: Shi H

PROVIDER: S-EPMC4177696 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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Chimeric antigen receptor for adoptive immunotherapy of cancer: latest research and future prospects.

Shi Huan H Sun Meili M Liu Lin L Wang Zhehai Z

Molecular cancer 20140921

Chimeric antigen receptors (CARs) are recombinant receptors that combine the specificity of an antigen-specific antibody with the T-cell's activating functions. Initial clinical trials of genetically engineered CAR T cells have significantly raised the profile of T cell therapy, and great efforts have been made to improve this approach. In this review, we provide a structural overview of the development of CAR technology and highlight areas that require further refinement. We also discuss critic ...[more]

PMID: 25241075

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