Ontology highlight
ABSTRACT:
SUBMITTER: Smith MA
PROVIDER: S-EPMC4177944 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Smith M A MA Hoffman L M LM Beckerle M C MC
Trends in cell biology 20140602 10
The actin cytoskeleton assembles into branched networks or bundles to generate mechanical force for critical cellular processes such as establishment of polarity, adhesion, and migration. Stress fibers (SFs) are contractile actomyosin structures that physically couple to the extracellular matrix through integrin-based focal adhesions (FAs), thereby transmitting force into and across the cell. Recently, LIN-11, Isl1, and MEC-3 (LIM) domain proteins have been implicated in mediating this cytoskele ...[more]