Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography.
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ABSTRACT:
SUBMITTER: Tran EE
PROVIDER: S-EPMC4178867 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography.
Tran Erin E H EE Simmons James A JA Bartesaghi Alberto A Shoemaker Charles J CJ Nelson Elizabeth E White Judith M JM Subramaniam Sriram S
Journal of virology 20140709 18
The Ebola virus glycoprotein mucin-like domain (MLD) is implicated in Ebola virus cell entry and immune evasion. Using cryo-electron tomography of Ebola virus-like particles, we determined a three-dimensional structure for the full-length glycoprotein in a near-native state and compared it to that of a glycoprotein lacking the MLD. Our results, which show that the MLD is located at the apex and the sides of each glycoprotein monomer, provide a structural template for analysis of MLD function. ...[more]
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