Ontology highlight
ABSTRACT: 0.05). In conclusion, our work clearly illustrates some promises and pitfalls of DNA methylation investigations on peripheral blood DNA in large epidemiological cohorts. DNA methylation levels at SLC19A2 are influenced by SNPs in LD with FV Leiden, but these DNA methylation marks do not explain the incomplete penetrance of the FV Leiden mutation.
SUBMITTER: Aissi D
PROVIDER: S-EPMC4179266 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Aïssi Dylan D Dennis Jessica J Ladouceur Martin M Truong Vinh V Zwingerman Nora N Rocanin-Arjo Ares A Germain Marine M Paton Tara A TA Morange Pierre-Emmanuel PE Gagnon France F Trégouët David-Alexandre DA
PloS one 20140929 9
In order to investigate whether DNA methylation marks could contribute to the incomplete penetrance of the FV Leiden mutation, a major genetic risk factor for venous thrombosis (VT), we measured genome-wide DNA methylation levels in peripheral blood samples of 98 VT patients carrying the mutation and 251 VT patients without the mutation using the dedicated Illumina HumanMethylation450 array. The genome-wide analysis of 388,120 CpG probes identified three sites mapping to the SLC19A2 locus whose ...[more]