Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC6430831 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Zhao Yun Y Zagani Rachid R Park Sung-Moo SM Yoshida Naohiro N Shah Pankaj P Reinecker Hans-Christian HC
Nature communications 20190322 1
During infection, transcription factor interferon regulatory factor 5 (IRF5) is essential for the control of host defense. Here we show that the microtubule-associated guanine nucleotide exchange factor (GEF)-H1, is required for the phosphorylation of IRF5 by microbial muramyl-dipeptides (MDP), the minimal structural motif of peptidoglycan of both Gram-positive and Gram-negative bacteria. Specifically, GEF-H1 functions in a microtubule based recognition system for microbial peptidoglycans that m ...[more]