Ontology highlight
ABSTRACT:
SUBMITTER: Peng M
PROVIDER: S-EPMC4181352 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Peng Min M Yin Na N Li Ming O MO
Cell 20140901 1
Mechanistic target of rapamycin complex 1 (mTORC1) integrates diverse environmental signals to control cellular growth and organismal homeostasis. In response to nutrients, Rag GTPases recruit mTORC1 to the lysosome to be activated, but how Rags are regulated remains incompletely understood. Here, we show that Sestrins bind to the heterodimeric RagA/B-RagC/D GTPases, and function as guanine nucleotide dissociation inhibitors (GDIs) for RagA/B. Sestrin overexpression inhibits amino-acid-induced R ...[more]