Application of scaling factors in simultaneous modeling of microarray data from diverse chips.
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ABSTRACT:
SUBMITTER: Yao Z
PROVIDER: S-EPMC4181592 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Publications
Application of scaling factors in simultaneous modeling of microarray data from diverse chips.
Yao Zhenling Z Zhao Baiteng B Hoffman Eric P EP Ghimbovschi Svetlana S DuBois Debra C DC Almon Richard R RR Jusko William J WJ
Pharmaceutical research 20070221 4
<h4>Purpose</h4>Microarrays have been utilized in many biological, physiological and pharmacological studies as a high-throughput genomic technique. Several generations of Affymetrix GeneChip microarrays are widely used in gene expression studies. However, differences in intensities of signals for different probe sets that represent the same gene on various types of Affymetrix chips make comparison of datasets complicated.<h4>Materials and methods</h4>A power coefficient scaling factor was appli ...[more]
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