Ontology highlight
ABSTRACT:
SUBMITTER: Huang G
PROVIDER: S-EPMC4181708 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Huang Guanyi G Yan Hexin H Ye Shoudong S Tong Chang C Ying Qi-Long QL
Stem cells (Dayton, Ohio) 20140501 5
STAT3 can be transcriptionally activated by phosphorylation of its tyrosine 705 or serine 727 residue. In mouse embryonic stem cells (mESCs), leukemia inhibitory factor (LIF) signaling maintains pluripotency by inducing JAK-mediated phosphorylation of STAT3 Y705 (pY705). However, the function of phosphorylated S727 (pS727) in mESCs remains unclear. In this study, we examined the roles of STAT3 pY705 and pS727 in regulating mESC identities, using a small molecule-based system to post-translationa ...[more]