Ontology highlight
ABSTRACT:
SUBMITTER: Lin WH
PROVIDER: S-EPMC7843420 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Lin Wei-Hsin WH Chang Yi-Wen YW Hong Min-Xiang MX Hsu Te-Cheng TC Lee Ko-Chuan KC Lin Che C Lee Jia-Lin JL
Oncogene 20201201 4
Epithelial-mesenchymal transition (EMT)/mesenchymal-epithelial transition (MET) processes are proposed to be a driving force of cancer metastasis. By studying metastasis in bone marrow-derived mesenchymal stem cell (BM-MSC)-driven lung cancer models, microarray time-series data analysis by systems biology approaches revealed BM-MSC-induced signaling triggers early dissemination of CD133<sup>+</sup>/CD83<sup>+</sup> cancer stem cells (CSCs) from primary sites shortly after STAT3 activation but pr ...[more]