Ontology highlight
ABSTRACT:
SUBMITTER: Tsao CM
PROVIDER: S-EPMC4182482 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Tsao Cheng-Ming CM Jhang Jhih-Gang JG Chen Shiu-Jen SJ Ka Shuk-Man SM Wu Tao-Cheng TC Liaw Wen-Jinn WJ Huang Hsieh-Chou HC Wu Chin-Chen CC
PloS one 20140930 9
Selegiline, an anti-Parkinson drug, has antioxidant and anti-apoptotic effects. To explore the effect of selegiline on sepsis, we used a clinically relevant animal model of polymicrobial sepsis. Cecal ligation and puncture (CLP) or sham operation was performed in male rats under anesthesia. Three hours after surgery, animals were randomized to receive intravenously selegiline (3 mg/kg) or an equivalent volume of saline. The administration of CLP rats with selegiline (i) increased arterial blood ...[more]