Ontology highlight
ABSTRACT:
SUBMITTER: Lv L
PROVIDER: S-EPMC4183148 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Lv Lei L Xu Yan-Ping YP Zhao Di D Li Fu-Long FL Wang Wei W Sasaki Naoya N Jiang Ying Y Zhou Xin X Li Ting-Ting TT Guan Kun-Liang KL Lei Qun-Ying QY Xiong Yue Y
Molecular cell 20131010 3
Alternative splicing of the PKM2 gene produces two isoforms, M1 and M2, which are preferentially expressed in adult and embryonic tissues, respectively. The M2 isoform is reexpressed in human cancer and has nonmetabolic functions in the nucleus as a protein kinase. Here, we report that PKM2 is acetylated by p300 acetyltransferase at K433, which is unique to PKM2 and directly contacts its allosteric activator, fructose 1,6-bisphosphate (FBP). Acetylation prevents PKM2 activation by interfering wi ...[more]