Ontology highlight
ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC4183597 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Zhang Fan F Paramasivam Manikandan M Cai Qian Q Dai Xiaoxia X Wang Pengcheng P Lin Krystal K Song Jikui J Seidman Michael M MM Wang Yinsheng Y
Journal of the American Chemical Society 20140909 37
Arsenic is a widespread environmental contaminant. However, the exact molecular mechanisms underlying the carcinogenic effects of arsenic remain incompletely understood. Core histones can be ubiquitinated by RING finger E3 ubiquitin ligases, among which the RNF20-RNF40 heterodimer catalyzes the ubiquitination of histone H2B at lysine 120. This ubiquitination event is important for the formation of open and biochemically accessible chromatin fiber that is conducive for DNA repair. Herein, we foun ...[more]