Ontology highlight
ABSTRACT:
SUBMITTER: deGruyter JN
PROVIDER: S-EPMC4184443 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Organic letters 20140923 19
The first asymmetric total synthesis and revision of the relative configuration of the 12-membered taumycin A macrocycle is described. Key to the success of this work was a novel α-keto ketene macrocyclization that provided an efficient means by which to access two diastereomers of the desired macrolide without the need to employ additional coupling agents or unnecessary oxidation state adjustments. ...[more]