Ontology highlight
ABSTRACT:
SUBMITTER: Yuan TL
PROVIDER: S-EPMC4184972 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Yuan Tina L TL Fellmann Christof C Lee Chih-Shia CS Ritchie Cayde D CD Thapar Vishal V Lee Liam C LC Hsu Dennis J DJ Grace Danielle D Carver Joseph O JO Zuber Johannes J Luo Ji J McCormick Frank F Lowe Scott W SW
Cancer discovery 20140806 10
<h4>Unlabelled</h4>RNAi is a powerful tool for target identification and can lead to novel therapies for pharmacologically intractable targets such as KRAS. RNAi therapy must combine potent siRNA payloads with reliable in vivo delivery for efficient target inhibition. We used a functional "Sensor" assay to establish a library of potent siRNAs against RAS pathway genes and to show that they efficiently suppress their targets at low dose. This reduces off-target effects and enables combination gen ...[more]