KRAS mutant lung cancer: progress thus far on an elusive therapeutic target.
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ABSTRACT:
SUBMITTER: Bhattacharya S
PROVIDER: S-EPMC4678136 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Publications
KRAS mutant lung cancer: progress thus far on an elusive therapeutic target.
Bhattacharya Saveri S Socinski Mark A MA Burns Timothy F TF
Clinical and translational medicine 20151214 1
The KRAS mutation remains the most common driver mutation in patients with non-small cell lung cancer (NSCLC) and confers a poor prognosis. Thus far, efforts to target this mutation over the last two decades have been unsuccessful. Over the past 5 years, many efforts to develop drugs that target the RAS-RAF-MEK-ERK (MAPK) pathway have resulted in enhanced understanding of the KRAS mutant NSCLC and have provided optimism that this disease can be targeted. ...[more]
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