Ontology highlight
ABSTRACT:
SUBMITTER: Eubanks LM
PROVIDER: S-EPMC4185020 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Eubanks Lisa M LM Ellis Beverly A BA Cai Xiaoqing X Schlosburg Joel E JE Janda Kim D KD
Bioorganic & medicinal chemistry letters 20140821 19
Cocaine abuse remains prevalent worldwide and continues to be a major health concern; nonetheless, there is no effective therapy. Immunopharmacotherapy has emerged as a promising treatment strategy by which anti-cocaine antibodies bind to the drug blunting its effects. Previous passive immunization studies using our human monoclonal antibody, GNCgzk, resulted in protection against cocaine overdose and acute toxicity. To further realize the clinical potential of this antibody, a recombinant IgG f ...[more]