Ontology highlight
ABSTRACT:
SUBMITTER: Zellweger RM
PROVIDER: S-EPMC4185219 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Zellweger Raphaël M RM Eddy William E WE Tang William W WW Miller Robyn R Shresta Sujan S
Journal of immunology (Baltimore, Md. : 1950) 20140912 8
Dengue virus (DENV) causes pathologies ranging from the febrile illness dengue fever to the potentially lethal severe dengue disease. A major risk factor for developing severe dengue disease is the presence of subprotective DENV-reactive Abs from a previous infection (or from an immune mother), which can induce Ab-dependent enhancement of infection (ADE). However, infection in the presence of subprotective anti-DENV Abs does not always result in severe disease, suggesting that other factors infl ...[more]